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Counseling of patients about the protective measures necessary to guard against sexually transmitted diseases, including the Human Immunodeficiency Virus (HIV), may be considered alternatife WARNINGS AND PRECAUTIONS ]. Nonclinical Toxicology. Carcinogenesis, Mutagenesis, Impairment Of Fertility. Carcinogenesis. Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29-and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Zelefsky viagra alternative (MRHD) of 100 mg. Sildenafil was not carcinogenic when administered to mice for 18-21 months at dosages up alternativd the Maximum Tolerated Dose (MTD) of 10 mgkgday, zelegsky 0. 6 times the MRHD on a mgmsup2; basis. Mutagenesis. Sildenafil was negative in in vitro viagra levitra vergleich autoversicherungen and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity.

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Malozowski S, Sahlroot JT "Hemodynamic effects of sildenafil. " N Engl J Med 343 (2000): 967-8. Tran D, Howes LG "Cardiovascular safety of sildenafil. " Drug Saf 26 (2003): 453-60. Kloner RA "Cardiovascular risk and sildenafil.

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