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Product Description

Applies to sildenafil: intravenous solution, oral suspension, oral tablet. The most common adverse reactions reported in clinical trials are headache, flushing, dyspepsia, abnormal vision, viagra buy generic lunesta congestion, back pain, myalgia, nausea, dizziness, and rash. [Ref] Cardiovascular. Very common (10 or more): Flushing (10) Uncommon (0. 1 to 1): Heart rate increased, palpitations, tachycardia, hypertension, hypotension.

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Detailed information

1): Hypersensitivity reactions, including rash and urticaria [Ref] Frequency not reported: Liver function tests abnormal [Ref] References. Cerner Multum, Inc. "Australian Product Information.

Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96 bound to plasma proteins. Protein binding is independent of total drug concentrations. Based upon measurements of sildenafil in semen of healthy volunteers 90 minutes after dosing, less than 0. 001 of the administered dose may appear in the semen of patients. Metabolism and Excretion. Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes.

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