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" Ophthalmology 109 (2002): 584-7. Jagle H, Jagle C, Serey L, et al. "Visual short-term effects of viagra: double-blind study in healthy young subjects. " Am J Ophthalmol 137 (2004): 842-9. Milman HA, Arnold SB "Neurologic, psychological, and aggressive disturbances with sildenafil. " Ann Pharmacother 36 (2002): 1129-34.

Detailed information

Do not stop using any medications without first talking to your doctor. sildenafil 8596; food.

Le sildeacute;nafil est principalement meacute;taboliseacute; par les isoenzymes 3A4 (voie principale) et 2C9 (voie secondaire) du cytochrome P450 (CYP). Donc, les inhibiteurs de ces isoenzymes peuvent diminuer la clairance du sildeacute;nafil et les inducteurs de ces isoenzymes peuvent augmenter la clairance du sildeacute;nafil. L'analyse pharmacocineacute;tique de population des donneacute;es issues des essais cliniques a montreacute; une diminution de la clairance du sildeacute;nafil lors de l'administration concomitante d'inhibiteurs du CYP3A4 (tels que le keacute;toconazole, l'eacute;rythromycine, la cimeacute;tidine). Bien que l'incidence des effets indeacute;sirables n'ait pas eacute;teacute; augmenteacute;e chez ces patients, lors de l'administration concomitante de sildeacute;nafil et d'inhibiteurs du CYP3A4, une posologie initiale de 25 mg doit ecirc;tre envisageacute;e.

Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient.]