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They then isolated and studied the molecules that trigger these proteins. It had long been accepted that cGMP inhibited the clumping of platelets but, to Dr Du's surprise, cGMP also seemed to encourage clumping. The researchers believe that cGMP initially causes platelets to stick together to seal a wound, but later reverses to stop an excessive build up of cells that could block a blood vessel. Viagra works by inhibiting an enzyme that breaks down cGMP. In tests Viagra alone did not promote clumping of platelets.

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