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Renal Impairment. No dose adjustment is required for mild (CLcr50-80 mLmin) and moderate (CLcr30-49 mLmin) renal impairment. In volunteers with severe renal impairment (Clcr lt; 30 mLmin), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil ( 2 fold), approximately doubling of Cmax and AUC. A starting dose of 25 mg should be considered in patients with severe renal impairment [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY ].

A surgeon removes your abnormal blood vessels, scar tissue, or blood. Retinal translocation. It's a procedure that destroys abnormal blood vessels in your eye that are directly under the center of your macula.

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