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Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes. Symptoms of a stroke may include confusion, vision or speech changes, one-sided weakness, or fainting.

It is the terminal of the axons of the parasympathetic nerves that release NO. The mechanism that causes erection is then the one shown above. The engorged sinusoids of the corpi cavernosi compress the penile veins, which reduces blood outflow from the penis. Blood is therefore trapped in the penis, which maintains the erection. The cycle of transformations of guanosine triphosphate is shown in more detail below (GC-Guanosine cyclase): Those 7 types of PDE are summerised in the table below. The Km values are equivalent to measurements of the tightness of binding (or affinity) of enzyme (PDE) to substrate (cGMP).

Unsurprisingly, erectile dysfunction tends to not pop up regularly in conversation. After all, impotence can strike at the heart of even the strongest relationship. It's understandable there's a reticence to go on record and talk about personal experiences of it.]