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Some small clinical trials have demonstrated that chronic PDE5 inhibition improves cardiac performance and geometry in various clinical conditions, including heart failure, myocardial infarction and diabetic cardiomyopathy.

Webster LJ, Michelakis ED, Davis T, Archer SL "Use of sildenafil for safe improvement of erectile function and quality of life in men with New York Heart Association classes II and III congestive heart failure: a prospective, placebo-controlled, double-blind crossover trial. " Arch Intern Med 164 (2004): 514-20. Kloner RA, Zusman RM "Cardiovascular effects of sildenafil citrate and recommendations for its use. " Am J Cardiol 84 (1999): n11-7.

Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients andor to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.]