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For Viagra to work, the nerves and blood vessels need to be functioning.

In the last sixteen years pre-clinical and clinical research into the extra-urological effects of PDE5i has expanded dramatically, revealing previously unsuspected indications for these drugs. Once more, the blue pill could change the quality of life of millions of people. Our meta-analytic research just published in BMC Medicine originated to clarify some controversies emerging from the available human studies. We wanted to analyze if chronic PDE5i administration was cardioprotective and safe, and, if so, where the benefits were mainly seen: cardiac muscle, peripheral vessels, or both. We showed that continuous administration of Viagra improves cardiac performance and has an anti-remodeling effect without a major impact on vascular parameters, suggesting that it does indeed have a direct effect on the heart. The novelty of this meta-analysis is the identification of subgroups of patients that may benefit more from PDE5i: patients with cardiac hypertrophy and heart failure, and patients developing a maladaptive remodeling to different injuries, in which the cardiac pump no longer works well.

The body8217;s dependence on the drug may not be worth it.]