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The enzyme guanylate cyclase then converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). cGMP causes contraindicaciones del viagra en diabeticos y smooth muscle to relax, which causes an inflow of blood which then leads to an erection. cGMP is then hydrolysed back to the inactive GMP by phosphodiesteras type 5 (PDE5). The levels of cGMP are therefore controlled by the activation of cyclic nucleotide cyclase and the breakdown by PDE5. It is the latter that sildenafil acts upon. Men who suffer from erectile dysfunction often produce too little amounts of NO.

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"[5] As far as its libido enhancing properties, two preclinical trials have found it effective in the animal model at improving sexual performance, confirming its aphrodisiacal properites. [6] ,[7] Saffron : this sacred spice, highly prized as both a culinary ingredient and medicine, has been studied to have significant effects in reversing erectile dysfunction at doses of 200 mg a day.

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