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Pfizer commissioned Taxi in Toronto to provide their angle on the viagra manufacturer offer for Viagra. On their site Taxi explain that they had to overcome perceptions built up by jokes on late night comedy shows. They had to show that this drug was visgra to benefit not just old men and sex fanatics but ordinary men. They aimed at visibility, universality, subtlety and vitality. In doing so they had to be careful not buying viagra online legal say a single word about Viagra as a product because of the Canadian laws on pharmaceutical advertising.

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Population pharmacokinetic data from patients in clinical trials also indicated a reduction in sildenafil clearance when it was co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS ]. In another study in healthy male volunteers, co-administration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg bid) with VIAGRA (100 mg single dose) resulted in a 300 (4-fold) increase in sildenafil Cmax and a 1000 (11-fold) increase in sildenafil plasma AUC. At 24 hours the plasma levels of sildenafil were still approximately 200 ngmL, compared to approximately 5 ngmL when sildenafil was dosed alone. This is consistent with ritonavir's marked effects on a broad range of P450 substrates. VIAGRA had no effect on ritonavir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS ].

To make sure Viagra is safe for you, tell your doctor if you have ever had: heart disease or heart rhythm problems, coronary artery disease; a heart attack, stroke, or congestive heart failure; high or low blood pressure; liver or kidney disease; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a bleeding disorder such as hemophilia; a stomach ulcer; retinitis pigmentosa (an inherited condition of the eye); a physical deformity of the penis (such as Peyronie's disease); or. if you have been told you should not have sexual intercourse for health reasons. Viagra can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old.]